DS07551382 | PTDSS1 inhibitor | Probechem Biochemicals

Chemical Structure : DS07551382

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DS07551382 (DS 07551382)

货号: PC-49675Not For Human Use, Lab Use Only.

DS07551382 (DS 07551382) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1), suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2.

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生物&药学活性

DS07551382 (DS 07551382) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1), suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2.
DS07551382 strongly suppressed the de novo PS synthesis in PTDSS2-KO HCT116 clone, whereas they weakly suppressed it in parental HCT116.
DS07551382 inhibits PS synthesis and induces ER stress in PTDSS2-deleted tumor cells.

物理化学性质&存储条件

分子量	554.91
分子式	C27H18ClF3N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(4-(4-(4-chlorophenoxy)-2-fluorophenyl)-5-(2,2-difluoropropyl)-6-oxo-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzo[d]oxazol-2(3H)-one

参考文献

1. Yohei Yoshihama, et al. Cancer Res. 2022 Nov 2;82(21):4031-4043.

DS07551382 (DS 07551382)

生物&药学活性

物理化学性质&存储条件

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DS07551382 (DS 07551382)

生物&药学活性

物理化学性质&存储条件

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