DS-70 |CAS 2733814-97-4 Probechem Biochemicals

Chemical Structure : DS-70

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DS-70 (α4 integrin inhibitor DS-70, DS70)

货号: PC-35545Not For Human Use, Lab Use Only.

DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity.

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生物&药学活性

DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity.
DS-70 prevents the adhesion of α4 integrin-expressing cells, antagonizes VCAM-1-mediated degranulation of mast cells and eosinophils and ERK 1/2 phosphorylation.
DS-70 does not inhibit cell adhesion mediated by the leukocyte integrins aLb2 and aMb2 or by the Arg-GlyAsp (RGD)-binding integrins α5β1, αVβ3, αVβ5, αVβ6 and αIIbβ3.
DS-70 dose-dependently reduces the clinical symptoms of allergic conjunctivitis, conjunctival α4 integrin expression and conjunctival levels of chemokines and cytokines in ovalbumin-sensitized guinea pigs.

物理化学性质&存储条件

分子量	438.484
分子式	C23H26N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(1-(2-(4-(3-(o-tolyl)ureido)phenyl)acetyl)pyrrolidine-3-carbonyl)glycine

参考文献

1. Dattoli SD, et al. Br J Pharmacol. 2018 Jul 26. doi: 10.1111/bph.14458.

DS-70 (α4 integrin inhibitor DS-70, DS70)

生物&药学活性

物理化学性质&存储条件

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DS-70 (α4 integrin inhibitor DS-70, DS70)

生物&药学活性

物理化学性质&存储条件

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