DS-1093a | HIF-PHD inhibitor | Probechem Biochemicals

Chemical Structure : DS-1093a

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DS-1093a (DS1093a)

货号: PC-22855Not For Human Use, Lab Use Only.

DS-1093a is a potent, selective and oral hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with EC50 of 0.49 uM (EPO production in Hep3B cells).

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生物&药学活性

DS-1093a is a potent, selective and oral hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with EC50 of 0.49 uM (EPO production in Hep3B cells).
DS-1093a (0.3, 1, and 3 mg/kg, oral) showed an increase in hemoglobin (Hgb) levels in rats with adenine-induced renal anemia.
DS-1093ahas a wide safety margin with potent in vitro activity and an optimal pharmacokinetic profile, compared with DS44470011.

物理化学性质&存储条件

分子量	518.61
分子式	C29H34N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(5-hydroxy-2-((1-(4'-(2-hydroxypropyl)-[1,1'-biphenyl]-4-yl)piperidin-4-yl)methyl)-6-methylpyrimidine-4-carbonyl)glycine

参考文献

1. Naoki Tanaka, et al. Bioorg Med Chem Lett. 2024 Jul 15:111:129891.

DS-1093a (DS1093a)

生物&药学活性

物理化学性质&存储条件

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DS-1093a (DS1093a)

生物&药学活性

物理化学性质&存储条件

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