DS-103 | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : DS-103

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DS-103 (DS103)

货号: PC-23992Not For Human Use, Lab Use Only.

DS-103 is a potent HDAC inhibitor with IC50 of 29/123/23/367 nM for HDAC1/2/3/6, weakly inhibits HDAC8 and no activity against class IIa member HDAC4.

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生物&药学活性

DS-103 is a potent HDAC inhibitor with IC50 of 29/123/23/367 nM for HDAC1/2/3/6, weakly inhibits HDAC8 and no activity against class IIa member HDAC4.
Inhibition of HDAC1 and HDAC3 is 4–5-fold higher than that of HDAC2 and 13-fold stronger than inhibition of HDAC6.
DS-103 displays 13-fold preference for HDAC1 and HDAC3 over HDAC6.
DS-103 demonstrates single-digit micromolar antiplasmodial activity (3D7 IC50 of 5.08 μM).
DS-103 displays a low single-digit micromolar inhibitor of cell proliferation in Cal27 (IC50: 1.47 μM) and Cal27CisR cells (IC50: 2.23 μM) aginst head-neck carcinoma cell line Cal27 and its cisplatin-resistant subline Cal27Cis.
DS-103 completely reversed cisplatin resistance in two different platinum-resistant solid cancer cell lines and demonstrated strong synergism with cisplatin.

物理化学性质&存储条件

分子量	487.60
分子式	C28H33N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-(Benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-[4-(2-ethylhydrazine-1-carbonyl)benzyl]benzamide

参考文献

1. Stopper D, et al. J Med Chem. 2025 Feb 13. doi: 10.1021/acs.jmedchem.4c02373.

DS-103 (DS103)

生物&药学活性

物理化学性质&存储条件

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DS-103 (DS103)

生物&药学活性

物理化学性质&存储条件

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