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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-DRILS-1398
DRILS-1398

Chemical Structure : DRILS-1398

CAS No.: 2562305-87-5

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DRILS-1398 (DRILS1398)

货号: PC-24816Not For Human Use, Lab Use Only.

DRILS-1398 is a potent inhibitor of M.tb chorismate mutase (M.tb-CM) with IC50 of 3.0 uM, demonstrates efficacy against multi-drug resistant M.tb strains (MIC=4 ug/mL), inhibits M.tb amino acid biosynthetic pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DRILS-1398 is a potent inhibitor of M.tb chorismate mutase (M.tb-CM) with IC50 of 3.0 uM, demonstrates efficacy against multi-drug resistant M.tb strains (MIC=4 ug/mL), inhibits M.tb amino acid biosynthetic pathway.
DRILS-1398 is capable of binding to the active site of the M.tb-CM and form a stable complex.
DRILS-1398 effectively inhibits intracellular M.tb in THP-1 macrophages.
Formulation of DRILS-1398 improves the pharmacokinetic and efficacy profile in the animal model.

物理化学性质&存储条件

分子量 436.34
分子式 C23H19Cl2N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-(5-chloro-1H-indol-3-yl)-5-(4-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine

参考文献

1. Deepesh Biswas, et al. iScience. 2025 Apr 29;28(6):112537.

2. Patent WO 2020/240272 A1.

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