DRI-C21095

Chemical Structure : DRI-C21095

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货号: PC-23563Not For Human Use, Lab Use Only.

DRI-C21095 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.17 uM in cell-free in vitro binding inhibition assay.

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生物&药学活性

DRI-C21095 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.17 uM in cell-free in vitro binding inhibition assay.
DRI-C21095 displays no activity against TNF-R1–TNF-α interaction.
DRI-C21095 concentration-dependently inhibits CD40L-induced marker expression (CD54, CD86, CD80, MHC-II) in THP cells
DRI-C21095 exhibits concentration-dependent inhibition of CD40L-induced human B-cell function with IC50 of 4.5 uM.
DRI-C21095 concentration-dependently inhibits CD40L-induced B cell proliferation.
DRI-C21095 (30 mg/kg; daily, s.c. in 20% HPβCD) exhibits prolongation of skin allograft in C57BL6 mice, inhibits alloantigen-induced T cell response in a draining lymph node.

物理化学性质&存储条件

分子量	656.71
分子式	C38H28N2O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4'-(4'-(methoxycarbonyl)-[1,1'-biphenyl]-4-carboxamido)-[1,1'-biphenyl]-4-carboxamido)naphthalene-1-sulfonic acid

参考文献

1. Chen J, et al. J Med Chem. (2017) 60:8906–22.

2. Bojadzic D, et al. Molecules. (2018) 23:1153.

DRI-C21095

生物&药学活性

物理化学性质&存储条件

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DRI-C21095

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