DRB18 | pan-GLUT inhibitor | Probechem Biochemicals

Chemical Structure : DRB18

CAS No.: 2863686-81-9

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DRB18 (DRB-18)

货号: PC-72387Not For Human Use, Lab Use Only.

DRB18 (DRB-18) is a potent, pan-class I glucose transporter (GLUT) inhibitor, reduces glucose uptake in HEK293 cell lines expressd single GLUT1-4 with IC50 of 0.9-8.8 uM.

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10 mg	￥3680	In stock
25 mg	￥5680	In stock
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生物&药学活性

DRB18 (DRB-18) is a potent, pan-class I glucose transporter (GLUT) inhibitor, reduces glucose uptake in HEK293 cell lines expressd single GLUT1-4 with IC50 of 0.9-8.8 uM.
DRB18 reduced cell viability in a dose-dependent manner in cancer cell lines (A549 IC50=3.5 uM, HeLa IC50=1.3 uM), also exhibited IC50 values < 10 μM in all nine melanoma cell lines.
DRB18 rapidly and potently inhibited glucose transport and glucose metabolism, inhibited multiple metabolic pathways associated with glucose metabolism in A549 cells.
DRB18 caused G1/S phase arrest and increased oxidative stress in A549 cells.
DRB18 (10mg/kg) inhibited the growth of A549 tumors xenografted in nude mice.

物理化学性质&存储条件

分子量	382.888
分子式	C22H23ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5'-(((4-chloro-1,2-phenylene)bis(azanediyl))bis(methylene))bis(2-methylphenol)

参考文献

1. Shriwas P, et al. Cancer Metab. 2021 Mar 26;9(1):14.

2. Roberts DA, et al. Bioorg Med Chem Lett. 2020 Sep 15; 30(18):127406.

DRB18 (DRB-18)

生物&药学活性

物理化学性质&存储条件

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DRB18 (DRB-18)

生物&药学活性

物理化学性质&存储条件

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