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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Chloride Channel-DRAinh-A270
DRAinh-A270

Chemical Structure : DRAinh-A270

CAS No.: 858753-48-7

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DRAinh-A270 (DRA inhitor A270)

货号: PC-38752Not For Human Use, Lab Use Only.

DRAinh-A270 is a small-molecule, selective inhibitor of intestinal anion exchanger SLC26A3 (DRA), inhibits SLC26A3-mediated chloride/bicarbonate exchange with IC50 of 35 nM and oxalate/chloride exchange with IC50 of 60 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DRAinh-A270 is a small-molecule, selective inhibitor of intestinal anion exchanger SLC26A3 (DRA), inhibits SLC26A3-mediated chloride/bicarbonate exchange with IC50 of 35 nM and oxalate/chloride exchange with IC50 of 60 nM.
    DRAinh-A270 effectively inhibits oxalate absorption by 70% in colonic closed loops in mice.
    DRAinh-A270 is effective in reducing intestinal oxalate absorption and preventing renal calcium oxalate deposition and injury in animal models of hyperoxaluria.

    物理化学性质&存储条件

    分子量 352.386
    分子式 C21H20O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4,8-dimethyl-7-((3-methylbenzyl)oxy)-2-oxo-2H-chromen-3-yl)acetic acid

    参考文献

    1. Cil O, et al. JCI Insight. 2021 Jun 8;6(11):e147699.

    2. Lee S, et al. J Med Chem. 2019;62(17):8330–8337.

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