DR2313 |CAS:284028-90-6 Probechem Biochemicals

Chemical Structure : DR2313

CAS No.: 284028-90-6

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DR2313 (DR 2313)

货号: PC-38045Not For Human Use, Lab Use Only.

DR2313 is a PARP inhibitor, inhibits poly(ADP-ribosyl)ation in nuclear extracts of rat brain in vitro (Ki=0.23 uM).

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100 mg	￥2980	In stock
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生物&药学活性

DR2313 is a PARP inhibitor, inhibits poly(ADP-ribosyl)ation in nuclear extracts of rat brain in vitro (Ki=0.23 uM).
DR2313 is specific for PARP but not selective between PARP-1 and PARP-2. DR2313 also shows excellent profiles in water solubility and rat brain penetrability.
DR2313 reduces excessive formation of poly(ADP-ribose) and cell death in in vitro models of cerebral ischemia.
DR2313 (10 mg/kg i.v. bolus and 10 mg/kg/h i.v. infusion for 6 h) significantly reduced the cortical infarct volume in both permanent and transient focal ischemia models in rats.
DR2313 exerts neuroprotective effects via its potent PARP inhibition.

物理化学性质&存储条件

分子量	182.241
分子式	C8H10N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one

参考文献

1. Nakajima H, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):472-81.

DR2313 (DR 2313)

生物&药学活性

物理化学性质&存储条件

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DR2313 (DR 2313)

生物&药学活性

物理化学性质&存储条件

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