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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-DQP-997-74
DQP-997-74

Chemical Structure : DQP-997-74

CAS No.: 2377187-09-0

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DQP-997-74

货号: PC-21031Not For Human Use, Lab Use Only.

DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 0.35 and 0.13 uM, respectively, exhibits >100-fold over GluN2A- and GluN2B-containing receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 0.35 and 0.13 uM, respectively, exhibits >100-fold over GluN2A- and GluN2B-containing receptors.

物理化学性质&存储条件

分子量 570.37
分子式 C28H19Cl2F2N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ClC1=CC=C(C(C2=CC=CC=C2N3)=C(C4=NN(C(C(F)(F)CC(O)=O)=O)[C@H](C5=CC=C(Cl)C=C5)C4)C3=O)C=C1

参考文献

1. Michael P. D'Erasmo, et al. ACS Chemical Neuroscience. August 11, 2023.

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