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首页-小分子抑制剂&激动剂-Others-Other Targets-DPTIP
DPTIP

Chemical Structure : DPTIP

CAS No.: 351353-48-5

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DPTIP

货号: PC-22881Not For Human Use, Lab Use Only.

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM.

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5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2680 In stock
50 mg ￥4380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM.
DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, decreases exosome release by 50% in astrocytes. DPTIP (10 mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release in vivo.

物理化学性质&存储条件

分子量 378.45
分子式 C21H18N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,6-Dimethoxy-4-(4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl)phenol

参考文献

1. Camilo Rojas, et al. Sci Rep. 2018 Dec 7;8(1):17715.

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