DPM-1001 |CAS:1471172-27-6 Probechem Biochemicals

Chemical Structure : DPM-1001

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DPM-1001 (DPM1001)

货号: PC-62543Not For Human Use, Lab Use Only.

DPM-1001 is a potent, selective, orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B with IC50 of 100 nM, also chelates copper, which enhanced its potency as a PTP1B inhibitor.

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生物&药学活性

DPM-1001 is a potent, selective, orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B with IC50 of 100 nM, also chelates copper, which enhanced its potency as a PTP1B inhibitor.
DPM-1001 displays anti-diabetic properties associated with enhanced signaling through insulin and leptin receptors in animal models of diet-induced obesity.

物理化学性质&存储条件

分子量	567.859
分子式	C35H57N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (R)-4-((3S,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-((4-((pyridin-2-ylmethyl)amino)butyl)amino)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

参考文献

1. Krishnan N, et al. J Biol Chem. 2018 Feb 2;293(5):1517-1525.

DPM-1001 (DPM1001)

生物&药学活性

物理化学性质&存储条件

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DPM-1001 (DPM1001)

生物&药学活性

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