DPI 201-106 (SDZ 201106)

Chemical Structure : DPI 201-106

CAS No.: 97730-95-5

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货号: PC-38569Not For Human Use, Lab Use Only.

DPI 201-106 (SDZ 201106) is a positive inotropic agent that prolongs the open state of cardiac voltage-gated Na+ channels.

规格	价格	库存
10 mg	￥680	In stock
25 mg	￥1180	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

DPI 201-106 (SDZ 201106) is a positive inotropic agent that prolongs the open state of cardiac voltage-gated Na+ channels.
DPI 201-106 produced concentration-dependent positive inotropic effects in guinea-pig and rat left atria, kitten, rabbit and guinea-pig papillary muscles and Langendorff perfused hearts of rabbits between 0.1-3 uM.
DPI 201-106 increased the Ca2+-sensitivity of skinned fibres from porcine trabecula septomarginalis with EC50 of 0.2 nM.
DPI (1-100 uM) suppressed the amplitude of delayed-rectifier K+ current (I(K(DR))) in a concentration-dependent manne with IC50 of 6.4 uM.
DPI-201106 also selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines.

物理化学性质&存储条件

分子量	466.58
分子式	C29H30N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[3-[4-(Diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile

参考文献

1. Scholtysik G, et al. Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):316-25.

2. Buggisch D, et al. Eur J Pharmacol. 1985 Dec 3;118(3):303-11.

3. Scholtysik G, et al. Eur J Pharmacol. 1986 Jun 5;125(1):111-8.

4. Hsiao SH, et al. Cancer Lett. 2018 Oct 10;434:81-90.