DPH | c-Abl activator | Probechem Biochemicals

Chemical Structure : DPH

CAS No.: 484049-04-9

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DPH (c-Abl activator DPH)

货号: PC-42883Not For Human Use, Lab Use Only.

DPH is a cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM).

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2680	In stock
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生物&药学活性

DPH is a cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM).
DPH binds to the myristoyl binding site, also stimulates in vitro c-Abl phosphorylation.
DPH induces both pY245 (pEC50=5.6) and pY412 c-Abl phosphorylation.
DPH dose dependently induces Crk-L pY207 in KG-1 cells.
DPH is the first small-molecule tool compound for c-Abl activation.

物理化学性质&存储条件

分子量	336.3198
分子式	C18H13FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Imidazolidinedione, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-

参考文献

1. Yang J, et al. Chem Biol. 2011 Feb 25;18(2):177-86.

2. Cabigas EB, et al. J Cardiovasc Pharmacol Ther. 2015 Jan;20(1):93-103.

3. Grover P, et al. PLoS One. 2015 Jul 29;10(7):e0133590.

DPH (c-Abl activator DPH)

生物&药学活性

物理化学性质&存储条件

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DPH (c-Abl activator DPH)

生物&药学活性

物理化学性质&存储条件

参考文献

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