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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-DPC168
DPC168

Chemical Structure : DPC168

CAS No.: 275810-55-4

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DPC168 (DPC-168)

货号: PC-73260Not For Human Use, Lab Use Only.

DPC168 (DPC-168) is a highly potent, selective CC chemokine receptor-3 (CCR3) antagonist with IC50 of 2.0 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.034 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DPC168 (DPC-168) is a highly potent, selective CC chemokine receptor-3 (CCR3) antagonist with IC50 of 2.0 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.034 nM.
    DPC168 demonstrates potency for mouse CCR3 (chemotaxis IC50=41 nM) and oral bioavailability in mice (20% F).
    DPC168 reduced eosinophil recruitment into the lungs in a dose-dependent manner in these animal models.

    物理化学性质&存储条件

    分子量 465.613
    分子式 C28H36FN3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Urea, N-(3-acetylphenyl)-N'-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]cyclohexyl]-

    参考文献

    1. De Lucca GV, et al. J Med Chem. 2005 Mar 24;48(6):2194-211.

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