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首页-小分子抑制剂&激动剂-Others-Translocator Protein (TSPO)-DPA-714
DPA-714

Chemical Structure : DPA-714

CAS No.: 958233-07-3

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DPA-714 (DPA714)

货号: PC-62197Not For Human Use, Lab Use Only.

DPA-714 is a potent, selective ligand for the translocator protein (TSPO) with Ki of 7.0 nM.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DPA-714 is a potent, selective ligand for the translocator protein (TSPO) with Ki of 7.0 nM.
DPA-714 decreases microglial activation and increase neuronal survival in a quinolinic acid rat model of excitotoxic neurodegeneration.
[18F]DPA-714 is a potential radiopharmaceutical for imaging TSPO in living systems using positron emission tomography (PET).

物理化学性质&存储条件

分子量 398.47
分子式 C22H27FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N-diethyl-2-[2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide

参考文献

1. James ML, et al. J Nucl Med. 2008 May;49(5):814-22.

2. Leaver KR, et al. ACS Chem Neurosci. 2012 Feb 15;3(2):114-9.

3. Reynolds A, et al. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5799-802.

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