DOI-NBOMe

Chemical Structure : DOI-NBOMe

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货号: PC-25986Not For Human Use, Lab Use Only.

DOI-NBOMe is a potent, selective and Gq-biased agonist of 5-HT2A receptor (5-HT2AR) with pEC50 of 8.01.

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生物&药学活性

DOI-NBOMe is a potent, selective and Gq-biased agonist of 5-HT2A receptor (5-HT2AR) with pEC50 of 8.01.
DOI-NBOMe shows no agonism to the primary signalling of other serotonin receptors, such as 5-HT1AR, 5-HT2BR and 5-HT2CR.
DOI-NBOMe (2 mg/kg) rapid and long-term antidepressant-like effects through activating 5-HT2AR, modulates freezing behaviour in corticosterone-induced depression-like mice.

物理化学性质&存储条件

分子量	441.31
分子式	C19H24INO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)propan-2-amine

参考文献

1. Zheng Xu, et al. Nature. 2026 Jan 28. doi: 10.1038/s41586-025-10061-7.

DOI-NBOMe

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物理化学性质&存储条件

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DOI-NBOMe

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物理化学性质&存储条件

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