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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-DNS-0056
DNS-0056

Chemical Structure : DNS-0056

CAS No.: 1513844-19-3

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DNS-0056 (DNS0056)

货号: PC-26397Not For Human Use, Lab Use Only.

DNS-0056 is a potent, selective, orally bioavailable and brain-penetrating PDE1B inhibitor with IC50 of 26 nM, 40-fold selective over PDE10A.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DNS-0056 is a potent, selective, orally bioavailable and brain-penetrating PDE1B inhibitor with IC50 of 26 nM, 40-fold selective over PDE10A.
DNS-0056 exhibits good selectivity with regard to other PDE families.
DNS-0056 shows potent memory-enhancing effects in a rat model of object recognition memory.

物理化学性质&存储条件

分子量 483.56
分子式 C24H26FN5O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one

参考文献

1. Brian Dyck, et al. J Med Chem. 2017 Apr 27;60(8):3472-3483.

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