DNMT2 inhibitor 16 | DNMT2 inhibitor | Probechem Biochemicals

Chemical Structure : DNMT2 inhibitor 16

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DNMT2 inhibitor 16 (DNMT2-IN-2)

货号: PC-25447Not For Human Use, Lab Use Only.

DNMT2 inhibitor 16 is a potent, selective DNMT2 (TRDMT1) inhibitor with ITC KD of 3.04 uM, reduces m5C levels in MOLM-13 tRNA and synergizes with doxorubicin to impair cell viability, targeting a cryptic allosteric binding site.

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DNMT2 inhibitor 16 is a potent, selective DNMT2 (TRDMT1) inhibitor with ITC KD of 3.04 uM, reduces m5C levels in MOLM-13 tRNA and synergizes with doxorubicin to impair cell viability, targeting a cryptic allosteric binding site.

物理化学性质&存储条件

分子量	499.01
分子式	C26H31ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((1-((4-((2-amino-2-oxoethyl)amino)-1-(4-chlorophenyl)-4-oxobutan-2-yl)carbamoyl)cyclopropyl)methyl)-4-ethylbenzamide

参考文献

1. Frey AF, et al. iScience. 2025 Aug 5;28(9):113300.

DNMT2 inhibitor 16 (DNMT2-IN-2)

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DNMT2 inhibitor 16 (DNMT2-IN-2)

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物理化学性质&存储条件

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