DN200434 | ERRγ inverse agonist | Probechem Biochemicals

Chemical Structure : DN200434

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DN200434 (DN-200434, DN 200434)

货号: PC-72964Not For Human Use, Lab Use Only.

DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist.

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生物&药学活性

DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist.
DN200434 binds to key ERRγ binding pocket residues through four-way interactions.
DN200434 effectively upregulated iodide-handling genes and restored radioiodine avidity in ATC tumor lesions.
DN200434 enhanced ATC tumor radioiodine therapy susceptibility, markedly inhibiting tumor growth.
DN200434 shows higher potency than GSK5182.

物理化学性质&存储条件

分子量	456.63
分子式	C30H36N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(δE)-δ-[(4-Hydroxyphenyl)[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methylene]benzenebutanol

参考文献

1. Thoudam Debraj Singh, et al. Clin Cancer Res. 2019 Aug 15;25(16):5069-5081.

DN200434 (DN-200434, DN 200434)

生物&药学活性

物理化学性质&存储条件

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DN200434 (DN-200434, DN 200434)

生物&药学活性

物理化学性质&存储条件

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