DMX-5804 |CAS: 2306178-56-1 Probechem Biochemicals

Chemical Structure : DMX-5804

CAS No.: 2306178-56-1

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DMX-5804 (DMX5804;DMX 5804)

货号: PC-36139Not For Human Use, Lab Use Only.

DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM.

规格	价格	库存
5 mg	￥2380	In stock
10 mg	￥3680	In stock
25 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM.
DMX-5804 displays >100-fold selectivity over GCK/MAP4K2, GLK/MAP4K3, KHS/MAP4K5 and VEGFR.
DMX-5804 rescues cell survival, mitochondrial function, and calcium cycling in hiPSC-CMs (human induced-pluripotent-stem-cell-derived cardiomyocytes), protects hiPSC-CMs with EC50 of 500 nM for cell death induced by 400 uM H2O.
DMX-5804 reduces infarct size and ischemia-reperfusion injury in mice in mice.

物理化学性质&存储条件

分子量	361.401
分子式	C21H19N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

参考文献

1. Fiedler LR, et al. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X.

DMX-5804 (DMX5804;DMX 5804)

生物&药学活性

物理化学性质&存储条件

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DMX-5804 (DMX5804;DMX 5804)

生物&药学活性

物理化学性质&存储条件

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