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首页-小分子抑制剂&激动剂-Others-Other Targets-DMT1 inhibitor 14a
DMT1 inhibitor 14a

Chemical Structure : DMT1 inhibitor 14a

CAS No.: 1062600-87-6

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DMT1 inhibitor 14a (XEN602 analog 3)

货号: PC-38325Not For Human Use, Lab Use Only.

DMT1 inhibitor 14a is a potent inhibitor of divalent metal transporter 1 (DMT1) with IC50 of 340 nM in calcein fluorescence assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DMT1 inhibitor 14a is a potent inhibitor of divalent metal transporter 1 (DMT1) with IC50 of 340 nM in calcein fluorescence assay.
    DMT1 inhibitor 14a demonstrated significant iron absorption inhibition in vivo with both 25 and 50 mg/kg doses in an acute rat model of iron hyperabsorption.

    物理化学性质&存储条件

    分子量 346.467
    分子式 C16H15FN4OS2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    参考文献

    1. Zaihui Zhang, et al. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5108-13.

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