DMP-777 |CAS:157341-41-8 Probechem Biochemicals

Chemical Structure : DMP-777

CAS No.: 157341-41-8

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DMP-777 (L-694458, DMP777)

货号: PC-45963Not For Human Use, Lab Use Only.

DMP-777 (L-694458, DMP777) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor with IC50 of 23 nM.

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10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

DMP-777 (L-694458, DMP777) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor with IC50 of 23 nM.
DMP-777 displays >40-fold selectivity over thrombin and chymotrypsin.
DMP-777 leads to the rapid emergence of spasmolytic polypeptide/trefoil factor family 2 (TFF2)-expressing metaplasia (SPEM) from the bases of fundic glands in gastrin-deficient mice.

物理化学性质&存储条件

分子量	564.6725
分子式	C31H40N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Azetidinecarboxamide, N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-, (2S)-

参考文献

1. Cvetovich RJ, et al. J Org Chem. 1996 Sep 20;61(19):6575-6580.

2. Nozaki K, et al. Gastroenterology. 2008 Feb;134(2):511-22.

3. Macdonald SJ, et al. J Med Chem. 1998 Oct 8;41(21):3919-22.

DMP-777 (L-694458, DMP777)

生物&药学活性

物理化学性质&存储条件

参考文献

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DMP-777 (L-694458, DMP777)

生物&药学活性

物理化学性质&存储条件

参考文献

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