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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-DMJ-I-228
DMJ-I-228

Chemical Structure : DMJ-I-228

CAS No.: 1374035-59-2

DMJ-I-228 ((+)-DMJ-I-228)

货号: PC-70320Not For Human Use, Lab Use Only.

DMJ-I-228 is a small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DMJ-I-228 is a small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM.

    物理化学性质&存储条件

    分子量 435.84
    分子式 C19H19ClFN5O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N1-(4-chloro-3-fluorophenyl)-N2-((1S,2S)-2-guanidino-2,3-dihydro-1H-inden-1-yl)oxalamide formate

    参考文献

    1. Madani N, et al. Structure. 2008 Nov 12; 16(11):1689-701.

    2. Richard J, et al. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2687-94.

    3. LaLonde JM, et al. J Med Chem. 2012 May 10;55(9):4382-96.

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