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首页-小分子抑制剂&激动剂-Epigenetics-DNA Methyltransferase (DNMT)-DMI46
DMI46

Chemical Structure : DMI46

CAS No.:

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DMI46 (DMI-46)

货号: PC-26538Not For Human Use, Lab Use Only.

DMI46 is a potent, selective inhibitor of DNA methyltransferase 1 (DNMT1), reverses cancer-specific DNA methylation abnormalities and tumor suppressor genes (TSGs) silencing, leading to robust antileukemic effects.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DMI46 is a potent, selective inhibitor of DNA methyltransferase 1 (DNMT1), reverses cancer-specific DNA methylation abnormalities and tumor suppressor genes (TSGs) silencing, leading to robust antileukemic effects.

物理化学性质&存储条件

分子量 533.65
分子式 C27H31N7O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(6-((2-amino-1-(4-methoxyphenyl)-2-oxoethyl)thio)-3,5-dicyano-4-ethyl-1H-pyrrolo[2,3b]pyridin-1-yl)-N-(2-(dimethylamino)ethyl)-N-methylacetamide

参考文献

1. Tang S, et al. Proc Natl Acad Sci U S A. 2026 Apr 14;123(15):e2532472123.

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