DMH-1 | BMP inhibitor | Probechem Biochemicals

Chemical Structure : DMH-1

CAS No.: 1206711-16-1

加入收藏

DMH-1 (DMH1, DMH 1)

货号: PC-42935Not For Human Use, Lab Use Only.

DMH-1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor with IC50 of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DMH-1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor with IC50 of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.
DMH-1 significantly reduces the percentage of cells expressing the pluripotency marker proteins OCT4 and Nanog in both SM3 and CA6 cells, induces regulation of pluripotency and neural precursor marker mRNAs.
DMH-1 reduces the canonical phosphorylation of Smads 1,5 and 9, inhibits HeLa and MCF-7 cell proliferation;.
DMH-1 significantly reduces the tumor growth in human lung cancer xenograft model.

物理化学性质&存储条件

分子量	380.4418
分子式	C24H20N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 11.5 mg/mL
Chemical Name/SMILES	Quinoline, 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-

参考文献

1. Hao J, et al. ACS Chem Biol. 2010 Feb 19;5(2):245-53.

2. Cross EE, et al. ACS Chem Biol. 2011 Sep 16;6(9):952-61.

3. Hao J, et al. PLoS One. 2014 Mar 6;9(6):e90748.

4. Engers DW, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.

DMH-1 (DMH1, DMH 1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DMH-1 (DMH1, DMH 1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.