DMA-135 freebase | EV71 inhibitor | Probechem Biochemicals

Chemical Structure : DMA-135 freebase

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DMA-135 freebase (DMA135)

货号: PC-72586Not For Human Use, Lab Use Only.

DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.

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生物&药学活性

DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.
DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.
DMA-135 changes the local and global structure of the EV71 SLII IRES domain.
DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex.

物理化学性质&存储条件

分子量	323.360
分子式	C16H17N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-N-carbamimidoyl-5-(dimethylamino)-6-(phenylethynyl)pyrazine-2-carboxamide

参考文献

1. Jesse Davila-Calderon, et al. Nat Commun. 2020 Sep 22;11(1):4775.

DMA-135 freebase (DMA135)

生物&药学活性

物理化学性质&存储条件

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DMA-135 freebase (DMA135)

生物&药学活性

物理化学性质&存储条件

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