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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Enterovirus-DMA-135
DMA-135

Chemical Structure : DMA-135

CAS No.: 2237925-62-9

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DMA-135 (DMA135)

货号: PC-72585Not For Human Use, Lab Use Only.

DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.
    DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.
    DMA-135 changes the local and global structure of the EV71 SLII IRES domain.
    DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex.

    物理化学性质&存储条件

    分子量 359.818
    分子式 C16H18ClN7O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-amino-N-carbamimidoyl-5-(dimethylamino)-6-(phenylethynyl)pyrazine-2-carboxamide hydrochloride

    参考文献

    1. Jesse Davila-Calderon, et al. Nat Commun. 2020 Sep 22;11(1):4775.

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