DM-PIT-1 | PIP3 antagonist | Probechem Biochemicals

Chemical Structure : DM-PIT-1

CAS No.: 701947-53-7

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DM-PIT-1 (3,5-dimethyl PIT-1)

货号: PC-62043Not For Human Use, Lab Use Only.

DM-PIT-1 is a specific PIP3 antagonist that disrupts PIP3/Akt PH domain, PIP3/PDK1 PH domain, and PIP3/GRP1 PH domain with IC50 of 27.1 uM, 80.5 uM, and 35.5 uM, respectively.

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25 mg	￥5480	In stock
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生物&药学活性

DM-PIT-1 is a specific PIP3 antagonist that disrupts PIP3/Akt PH domain, PIP3/PDK1 PH domain, and PIP3/GRP1 PH domain with IC50 of 27.1 uM, 80.5 uM, and 35.5 uM, respectively.
DM-PIT-1 suppresses the PI3K-PDK1-Akt pathway and triggers metabolic stress and apoptosis.
DM-PIT-1 inhibits in vivo tumor growth in BALB/c mice.
DM-PIT-1 is a dimethyl analog of PIT-1 with improved aqueous solubility.

物理化学性质&存储条件

分子量	345.4
分子式	C16H15N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[(2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-3,5-dimethyl-benzamide

参考文献

1. Miao B, et al. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.

2. Skidan I, et al. Drug Deliv. 2009 Jan;16(1):45-51.

3. Miao B, et al. Oncogene. 2012 Sep 27;31(39):4317-32.

DM-PIT-1 (3,5-dimethyl PIT-1)

生物&药学活性

物理化学性质&存储条件

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DM-PIT-1 (3,5-dimethyl PIT-1)

生物&药学活性

物理化学性质&存储条件

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