DM-NOFD | FIH inhibitor | Probechem Biochemicals

Chemical Structure : DM-NOFD

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DM-NOFD (Dimethyl ester NOFD;N-oxalyl-d-phenylalanine)

货号: PC-60850Not For Human Use, Lab Use Only.

DM-NOFD is the dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).

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生物&药学活性

DM-NOFD is the dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).
DM-NOFD also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM).
DM-NOFD is more efficiently reduces HIF1α CAD hydroxylation.

物理化学性质&存储条件

分子量	265.265
分子式	C13H15NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Dimethyl N-oxalyl-d-phenylalanine

参考文献

1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73.

2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1.

DM-NOFD (Dimethyl ester NOFD;N-oxalyl-d-phenylalanine)

生物&药学活性

物理化学性质&存储条件

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DM-NOFD (Dimethyl ester NOFD;N-oxalyl-d-phenylalanine)

生物&药学活性

物理化学性质&存储条件

参考文献

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