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DLin-MC3-DMA

Chemical Structure : DLin-MC3-DMA

CAS No.: 1224606-06-7

DLin-MC3-DMA (MC3)

货号: PC-73149Not For Human Use, Lab Use Only.

DLin-MC3-DMA is an ionizable amino lipid (apparent pKa = 6.44) that has been used in combination with other lipids in the formation of lipid nanoparticles.

规格 价格 库存 数量
5 mg ¥1280 In stock
10 mg ¥1880 In stock
25 mg ¥2980 In stock
50 mg ¥4780 In stock
100 mg ¥7580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DLin-MC3-DMA is an ionizable amino lipid (apparent pKa = 6.44) that has been used in combination with other lipids in the formation of lipid nanoparticles.
Administration of Factor VII siRNA in DLin-MC3-DMA-containing lipid nanoparticles reduces plasma Factor VII protein levels in mice.
Formulations containing DLin-MC3-DMA have been used in the development of lipid nanoparticles for siRNA delivery in patients with hereditary transthyretin-mediated amyloidosis.

物理化学性质&存储条件

分子量 642.1
分子式 C43H79NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

100 mM in Ethanol (64.2 mg/mL)

Chemical Name/SMILES

(6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

参考文献

1. Kulkarni JA, et al. Nanomedicine. 2017 May;13(4):1377-1387.

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