DLG-41

Chemical Structure : DLG-41

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货号: PC-25799Not For Human Use, Lab Use Only.

DLG-41 is a potent, selective inhibitor of GAS41 YEATS domain with IC50 of 610 nM in in AlphaLISA assays, binds to GAS41 YEATS domain with ITC KD of 1.0 uM.

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生物&药学活性

DLG-41 is a potent, selective inhibitor of GAS41 YEATS domain with IC50 of 610 nM in in AlphaLISA assays, binds to GAS41 YEATS domain with ITC KD of 1.0 uM.
DLG-41 blocks binding of GAS41 with chromatin in HEK293T cells with IC50 of 0.9 uM, with no activity for BRD4-BD1.
DLG-41 blocks proliferation of a panel of NSCLC cell lines in a GAS41 dependent manner (H1299 cell IC50=0.45 uM).
DLG-41 decreases global gene expression and ameliorates NSCLC phenotypes in H1299 cells, associated with lung cancer cell identity, tumor migration, and invasion.

物理化学性质&存储条件

分子量	601.78
分子式	C32H35N5O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4,4-Dimethyl-N-(5-(3-(5-(4-(propionamidomethyl)naphthalen-1-yl)thiazol-2-yl)azetidine-1-carbonyl)thiophen-2-yl)pyrrolidine-2-carboxamide

参考文献

1. Listunov D, et al. J Med Chem. 2025 Nov 26. doi: 10.1021/acs.jmedchem.5c02307.

DLG-41

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物理化学性质&存储条件

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DLG-41

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