DLCI-1 dihydrochloride

Chemical Structure : DLCI-1 dihydrochloride

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货号: PC-49015Not For Human Use, Lab Use Only.

DLCI-1 dihydrochloride is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

DLCI-1 dihydrochloride is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes.
DLCI-1 exhibit favorable metabolic stability and half-life in human liver microsomes.
DLCI-1 effectively attenuates intravenous nicotine self-administration in a mouse model.
DLCI-1 may serve as an effective therapeutic to promote tobacco and nicotine cessation.

物理化学性质&存储条件

分子量	291.234
分子式	C12H16Cl2N2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-(4-ethylpyridin-3-yl)thiophen-2-yl)methanamine dihydrochloride

参考文献

1. Yen-Chu Chen, et al. J Pharmacol Exp Ther. 2020 Jan;372(1):21-29.

2. Denton TT, et al. J Med Chem 61:7065–7086.