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首页-小分子抑制剂&激动剂-GPCR-GPR84-DL-175
DL-175

Chemical Structure : DL-175

CAS No.: 2487253-25-6

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DL-175 (DL175)

货号: PC-72367Not For Human Use, Lab Use Only.

DL-175 is a potent and selective biased GPR84 agonist with EC50 of 33 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DL-175 is a potent and selective biased GPR84 agonist with EC50 of 33 nM.
    DL-175 exhibits no significant activity in a panel of 168 other GPCRs.
    DL-175 display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, and human U937 cells.
    DL-175 markedly different abilities to induce chemotaxis in human myeloid cells, while causing similar levels of phagocytosis enhancement.

    物理化学性质&存储条件

    分子量 299.754
    分子式 C17H14ClNO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide

    参考文献

    1. Lucy D, et al. ACS Chem Biol. 2019 Sep 20;14(9):2055-2064.

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