DKM 3-42 |CAS:164925-73-9 Probechem Biochemicals

Chemical Structure : DKM 3-42

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DKM 3-42 (DKM3-42)

货号: PC-35381Not For Human Use, Lab Use Only.

DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity.

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生物&药学活性

DKM3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity.
DKM3-42 impairs A549 serum-survival in a dose-responsive manner.
DKM3-42 significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of 50mg/kg ip, once per day.

物理化学性质&存储条件

分子量	207.317
分子式	C13H21NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(3,7-dimethylocta-2,6-dien-1-yl)acrylamide

参考文献

1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381.

DKM 3-42 (DKM3-42)

生物&药学活性

物理化学性质&存储条件

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DKM 3-42 (DKM3-42)

生物&药学活性

物理化学性质&存储条件

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