DKFZ-748 | HDAC10 inhibitor | Probechem Biochemicals

Chemical Structure : DKFZ-748

CAS No.: 2490709-68-5

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DKFZ-748 (DKFZ748)

货号: PC-49363Not For Human Use, Lab Use Only.

DKFZ-748 (DKFZ748) is a potent, specific HDAC10 inhibitor with cellular IC50 of 22 nM, >500-fold selectivity over other HDAC isozymes.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DKFZ-748 (DKFZ748) is a potent, specific HDAC10 inhibitor with cellular IC50 of 22 nM, >500-fold selectivity over other HDAC isozymes.
Inhibition of HDAC10 activity via DKFZ-748 (5 uM) suppressed colon cancer cell growth rescue by N8-AcSpd in HCT116 WT cells.
DKFZ-748 treatment effectively prevented restoration of polyamine homeostasis by N8-AcSpd in HCT116 cells.
DKFZ-748 showed dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model.
DKFZ-748 is a valuable chemical probe for studies on the enigmatic biology of HDAC10 and acetylated polyamines in both physiological and pathological settings.

物理化学性质&存储条件

分子量	329.400
分子式	C18H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((4-(hydroxyamino)-4-oxobutyl)(methyl)amino)ethyl)-1-naphthamide

参考文献

1. Raphael R. Steimbach, et al. J. Am. Chem. Soc. 2022.

2. Tracy Murray Stewart, et al. J Biol Chem. 2022 Aug 19;298(10):102407.

DKFZ-748 (DKFZ748)

生物&药学活性

物理化学性质&存储条件

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DKFZ-748 (DKFZ748)

生物&药学活性

物理化学性质&存储条件

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