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首页-小分子抑制剂&激动剂-Others-Other Targets-DKC1125
DKC1125

Chemical Structure : DKC1125

CAS No.:

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DKC1125 (DKC-1125)

货号: PC-49384Not For Human Use, Lab Use Only.

DKC1125 is a small molecule KSRP-binding compound that specifically inhibits the oncogenic KITENIN complex, suppresses distant metastasis of colorectal cancer (CRC).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DKC1125 is a small molecule KSRP-binding compound that specifically inhibits the oncogenic KITENIN complex, suppresses distant metastasis of colorectal cancer (CRC).
    DKC1125 specifically interacted with the binding pocket of the fourth KH-domain of KSRP.
    DKC1125 degraded KITENIN and Dvl2 by recruiting RACK1 and miRNA-124, leading to the disintegration of the functional KITENIN–KSRP–RACK1–Dvl2 complex.
    DKC1125 restored sensitivity to 5-fluorouracil, oxaliplatin, and cetuximab by normalizing expression of the deregulated microRNAs, including miRNA-124 in KITENIN-overexpressing CRC cells.
    DKC1125 bound the KH-type splicing regulatory protein (KSRP), a downstream factor and stabilizer of the functional KITENIN complex, and specifically suppressed invasiveness of CRC cells expressing higher levels of KITENIN.
    DKC1125 significantly inhibited the increase in cellular invasion caused by ectopic KITENIN expression in Caco2 cells, starting at a concentration of 0.5 uM.
    DKC1125 inhibited the function of Dvl by interfering with the interaction of KSRP with Dvl2.

    物理化学性质&存储条件

    分子量 297.310
    分子式 C17H15NO4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((2-oxo-2-phenylethyl)carbamoyl)phenyl acetate

    参考文献

    1. Jeong A Bae, et al. Mol Cancer. 2021 May 26;20(1):78.

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