DK419 |CAS:2102672-22-8 Probechem Biochemicals

Chemical Structure : DK419

CAS No.: 2102672-22-8

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DK419 (DK-419;DK 419)

货号: PC-35711Not For Human Use, Lab Use Only.

DK419 (DK-419) a potent, orally acitve inhibitor of Wnt/β-catenin signaling with IC50 of 0.19 uM in Wnt3A-stimulated TOPFlash assays.

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5 mg	￥2580	In stock
25 mg	￥5980	In stock
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生物&药学活性

DK419 (DK-419) a potent, orally acitve inhibitor of Wnt/β-catenin signaling with IC50 of 0.19 uM in Wnt3A-stimulated TOPFlash assays.
DK419 reduces levels of Wnt/β-catenin target gene proteins (Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin) in CRC tumor cell models, increases oxygen consumption rate and induces pAMPK in cell culture.
DK419 potently inhibit the proliferation of CRC tumor cell lines (SW948 cell IC50=0.07 uM).
DK419 displays inhibition of tumor growth in mouse CRC240 PDX tumor model.

物理化学性质&存储条件

分子量	407.7
分子式	C16H8ClF6N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-2-(trifluoromethyl)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide

参考文献

1. Wang J, et al. Bioorg Med Chem. 2018 Sep 17. pii: S0968-0896(18)31138-6.

DK419 (DK-419;DK 419)

生物&药学活性

物理化学性质&存储条件

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DK419 (DK-419;DK 419)

生物&药学活性

物理化学性质&存储条件

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