DK2403 | MAP2K7 inhibitor Cat.No： | Probechem Biochemicals

Chemical Structure : DK2403

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DK2403 (DK-2403, DK 2403)

货号: PC-20654Not For Human Use, Lab Use Only.

DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.

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生物&药学活性

DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.
DK2403 (5-10 uM) decreased phosphorylation of JNK and ATF2 in T-ALL cells.
DK2403 showed virtually no activity against MEK4 (IC50 > 80 uM), and no appreciable activity on MEK1/2, p38α/β, or JNK1/2/3.
DK2403 displays potent and marked cytotoxicity in a variety of T-ALL cell lines (RPMI-8402 cell IC50=2.9 uM; ALL-SIL, IC50=1.1 uM).

物理化学性质&存储条件

分子量	368.82
分子式	C19H17ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((6-(benzylamino)pyrimidin-4-yl)oxy)phenyl)-2-chloroacetamide

参考文献

1. Dalton R. Kim, et al. ACS Med. Chem. Lett. April 17, 2023.

DK2403 (DK-2403, DK 2403)

生物&药学活性

物理化学性质&存储条件

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DK2403 (DK-2403, DK 2403)

生物&药学活性

物理化学性质&存储条件

参考文献

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