DJ503701 | FZD6 ligand, WNT inhibitor | Probechem Biochemicals

Chemical Structure : DJ503701

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DJ503701 (Compound 11)

货号: PC-26531Not For Human Use, Lab Use Only.

DJ503701 (compound 11) is a small molecule ligand competition binding at FZD6, efficiently counteractes WNT-3A-induced WNT–β-catenin signaling with IC50 of 1.2 uM.

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生物&药学活性

DJ503701 (compound 11) is a small molecule ligand competition binding at FZD6, efficiently counteractes WNT-3A-induced WNT–β-catenin signaling with IC50 of 1.2 uM.
Compound 11 binds nonselectively to the receptor core of FZDs.
Compound 11 targets the transmembrane core of FZDs and not the orthosteric WNT binding site on the cysteine-rich domain (CRD).
Compound 11 interferes with WNT-driven signaling in hepatocyte spheroids and pancreatic cancer cells.
Compound 11 reduces viability of RNF43-negative pancreatic cancer cells.

物理化学性质&存储条件

分子量	636.21
分子式	C37H34ClN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-([1,1'-biphenyl]-3-ylmethyl)-N-((1r,4r)-4-(3-acetamidobenzamido)cyclohexyl)-3-chlorobenzo[b]thiophene-2-carboxamide

参考文献

1. Lukas Grätz, et al. J Biol Chem. 2025 Nov;301(11):110751.

DJ503701 (Compound 11)

生物&药学活性

物理化学性质&存储条件

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DJ503701 (Compound 11)

生物&药学活性

物理化学性质&存储条件

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