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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-DJ4
DJ4

Chemical Structure : DJ4

CAS No.:

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DJ4 (ROCK inhibitor DJ4)

货号: PC-35150Not For Human Use, Lab Use Only.

DJ4 (ROCK inhibitor DJ4) is a potent, selective, ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DJ4 (ROCK inhibitor DJ4) is a potent, selective, ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM, respectively.
    DJ4 minimally inhibits PAK1 and DMPK, inhibits the phosphorylation of recombinant MYPT1(Thr696) by recombinant ROCK1 and ROCK2.
    DJ4 significantly blocks stress fiber formation and inhibits migration and invasion of multiple cancer cell lines in a concentration dependent manner, which is independent of cell death.

    物理化学性质&存储条件

    分子量 350.44
    分子式 C19H18N4OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2Z,5E)-5-((3a,7a-dihydro-1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-2-(phenethylimino)thiazolidin-4-one

    参考文献

    1. Kale VP, et al. Cancer Lett. 2014 Nov 28;354(2):299-310.

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