DJ-1 inhibitor comp-23 | DJ-1/PARK7 inhibitor | Probechem Biochemicals

Chemical Structure : DJ-1 inhibitor comp-23

CAS No.: 724737-74-0

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DJ-1 inhibitor comp-23 (Comp-23)

货号: PC-22171Not For Human Use, Lab Use Only.

DJ-1 inhibitor comp-23 is a small molecule binding to DJ-1 (PARK7) with binding constant (Kd) of 0.1 uM, exerts a neuroprotective effect by reducing ROS-mediated neuronal injury.

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50 mg	￥1380	In stock
100 mg	￥1980	In stock
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生物&药学活性

DJ-1 inhibitor comp-23 is a small molecule binding to DJ-1 (PARK7) with binding constant (Kd) of 0.1 uM, exerts a neuroprotective effect by reducing ROS-mediated neuronal injury.
Comp-23 prevents oxidative stress-induced death of SH-SY5Y cells and primary neuronal cells of the ventral mesencephalon but not that of DJ-1-knockdown SH-SY5Y cells.
Comp-23 exerts a neuroprotective effect by reducing ROS-mediated neuronal injury Comp-23 inhibited the production of reactive oxygen species (ROS) induced by oxidative stress and preventsexcess oxidation of DJ-1.
Comp-23 prevented dopaminergic cell death in the substantia nigra and restored movement abnormality in 6-hydroxyldopamine-injected and rotenone-treated PD model rats and mice.
Comp-23 also reduces infarct size of cerebral ischemia in rats that had been induced by middle cerebral artery occlusion.

物理化学性质&存储条件

分子量	417.47
分子式	C24H23N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4,5-trimethoxy-N-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

参考文献

1. Yoshihisa Kitamura, et al. Mol Neurodegener. 2011 Jul 8;6(1):48.

DJ-1 inhibitor comp-23 (Comp-23)

生物&药学活性

物理化学性质&存储条件

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DJ-1 inhibitor comp-23 (Comp-23)

生物&药学活性

物理化学性质&存储条件

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