DIZ-3

Chemical Structure : DIZ-3

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货号: PC-38838Not For Human Use, Lab Use Only.

DIZ-3 is a dimeric aryl-substituted imidazole as a selective multimeric G-quadruplex (G4) ligand, intercalates into the G4-G4 interface, induces cell cycle arrest and apoptosis, and inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cell lines, via targeting telomeric multimeric G4.

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生物&药学活性

DIZ-3 is a dimeric aryl-substituted imidazole as a selective multimeric G-quadruplex (G4) ligand, intercalates into the G4-G4 interface, induces cell cycle arrest and apoptosis, and inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cell lines, via targeting telomeric multimeric G4.

物理化学性质&存储条件

分子量	746.911
分子式	C46H44F2N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(5-(4-fluorophenyl)-2-(4-(4-(4-fluorophenyl)-5-(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)phenyl)-1H-imidazol-4-yl)phenyl)-4-methylpiperazine

参考文献

1. Ming-Hao Hu, et al. Eur J Med Chem. 2020 Jan 15;186:111891.

DIZ-3

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DIZ-3

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