DIMATE |CAS:350229-29-7 Probechem Biochemicals

Chemical Structure : DIMATE

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DIMATE (ALDH1 inhibitor DIMATE)

货号: PC-61351Not For Human Use, Lab Use Only.

DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor, displays cytotoxic activity on human AML cell lines with IC50 of 1-15 uM.

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生物&药学活性

DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor, displays cytotoxic activity on human AML cell lines with IC50 of 1-15 uM.
DIMATE shows selective cytotoxicity in leukemic population enriched in LSCs, with no cytotoxicity for healthy hematopoietic stem cells.
DIMATE promotes the accumulation of apoptogenic aldehydes leading to apoptosis and tumor growth inhibition in xenograft mouse models.

物理化学性质&存储条件

分子量	185.285
分子式	C9H15NOS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate

参考文献

1. Pérez-Alea M, et al. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.160.

2. Venton, et al. Blood Cancer J. 2016 Sep 9;6(9):e469.

3. Quash G, et al. Eur J Med Chem. 2008 May;43(5):906-16.

DIMATE (ALDH1 inhibitor DIMATE)

生物&药学活性

物理化学性质&存储条件

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DIMATE (ALDH1 inhibitor DIMATE)

生物&药学活性

物理化学性质&存储条件

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