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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-RAD51-DIDS
DIDS

Chemical Structure : DIDS

CAS No.: 304655-84-3

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DIDS

货号: PC-61230Not For Human Use, Lab Use Only.

DIDS is a small molecule inhibitor of RAD51-mediated homologous recombination.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DIDS is a small molecule inhibitor of RAD51-mediated homologous recombination.
    DIDS inhibits repair of activation-induced cytidine deaminase (AID)-initiated DNA breaks, induces apoptosis, and promotes cytotoxicity preferentially in AID-expressing human CLL;.
    DIDS strongly inhibits T1D development in NOD mice.

    物理化学性质&存储条件

    分子量 516.483
    分子式 C16H10N2Na2O7S4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4,4'-diisothiocyanatostilbene-2, 2'-disulfonic acid disodium hydrate

    参考文献

    1. Ratiu JJ, et al. J Immunol. 2017 Jun 1;198(11):4255-4267.

    2. Lamont KR, et al. Exp Med. 2013 May 6;210(5):1021-33.

    3. Dinnen RD, et al. Mol Cancer Ther. 2013 Dec;12(12):2792-803.

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