DI-591 |CAS:2245887-38-9 Probechem Biochemicals

Chemical Structure : DI-591

CAS No.: 2245887-38-9

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DI-591 (DI591)

货号: PC-60017Not For Human Use, Lab Use Only.

DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2.

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10 mg	￥5280	In stock
25 mg	￥8580	In stock
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生物&药学活性

DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2.
DI-591 displays no affinity against DCN3/4/5 (Ki>10 uM).
DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members.
DI-591 accumulates NRF2 protein and its transcriptional activation in cells.

物理化学性质&存储条件

分子量	585.808
分子式	C31H47N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((S)-1-cyclohexyl-2-(3-morpholinopropanamido)ethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide

参考文献

1. Zhou H, et al. Nat Commun. 2017 Oct 27;8(1):1150.

DI-591 (DI591)

生物&药学活性

物理化学性质&存储条件

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DI-591 (DI591)

生物&药学活性

物理化学性质&存储条件

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