DI-404 |CAS: 2187412-79-7 Probechem Biochemicals

Chemical Structure : DI-404

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DI-404 (DI404)

货号: PC-63182Not For Human Use, Lab Use Only.

DI-404 is a highly potent, peptidomimetic inhibitor of DCN1-UBC12 protein-protein interaction that bind to DCN1 protein with Kd of 6.9 nM, selectively inhibits the neddylation of cullin 3 over other cullin members.

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生物&药学活性

DI-404 is a highly potent, peptidomimetic inhibitor of DCN1-UBC12 protein-protein interaction that bind to DCN1 protein with Kd of 6.9 nM, selectively inhibits the neddylation of cullin 3 over other cullin members.
DI-404 effectively enhances the thermal stability of cellular DCN1 protein at 0.3 uM in H2170 cells, decreases the association of cellular DCN1 protein with cellular UBC12 protein in a dose-dependent manner.
DI-404 effectively increases the level of NRF2 protein, a substrate of cullin 3 CRL (CRL3), but has no effect on CDT1, a substrate of cullin 4A CRL (CRL4A).

物理化学性质&存储条件

分子量	713.291
分子式	C35H45ClN6O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-Amino-2-((S)-2-((S)-3-(6-chlorobenzo[d]thiazol-2-yl)-2-propionamidopropanamido)-2-(tetrahydro-2H-pyran-4-yl)-acetamido)-N-((R)-chroman-4-yl)hexanamide

参考文献

1. Zhou H, et al. J Med Chem. 2018 Mar 8;61(5):1934-1950.

DI-404 (DI404)

生物&药学活性

物理化学性质&存储条件

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DI-404 (DI404)

生物&药学活性

物理化学性质&存储条件

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