DI-1548 | DCN1 inhibitor | Probechem Biochemicals

Chemical Structure : DI-1548

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DI-1548 (DI 1548)

货号: PC-72230Not For Human Use, Lab Use Only.

DI-1548 (DI 1548) is a potent, selective and covalent DCN1 inhibitor with IC50 of 4.6 nM and Ki of <1 nM, does not bind to DCN3.

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生物&药学活性

DI-1548 (DI 1548) is a potent, selective and covalent DCN1 inhibitor with IC50 of 4.6 nM and Ki of <1 nM, does not bind to DCN3.
DI-1548 could inhibit cullin 3 neddylation at concentration as low as 1 nM, which is 1000 times more potent than DI-591.
DI-1548 selectively inhibit neddylation of cullin 3 in cells at low nanomolar concentrations and are 2-3 orders of magnitude more potent than our previously reported reversible DCN1 inhibitor DI-591.

物理化学性质&存储条件

分子量	597.819
分子式	C32H47N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-2-cyclohexyl-2-((S)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamido)ethyl)-2-(morpholinomethyl)acrylamide

参考文献

1. Haibin Zhou, et al. Nat Commun. 2021 May 11;12(1):2621.

DI-1548 (DI 1548)

生物&药学活性

物理化学性质&存储条件

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DI-1548 (DI 1548)

生物&药学活性

物理化学性质&存储条件

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