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首页-小分子抑制剂&激动剂-Others-Other Targets-DHX8-IN-1
DHX8-IN-1

Chemical Structure : DHX8-IN-1

CAS No.:

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DHX8-IN-1 (Compound 53)

货号: PC-27642Not For Human Use, Lab Use Only.

DHX8-IN-1 (Compound 53) is a potent, specific inhibitor of spliceosomal DEAH-box RNA helicase DHX8, inhibits DHX9 ATP-hydrolysis with IC50 of 43 nM in biochemical ADP-Glo assays, and 120 nM in RNA FA (fluorescence anisotropy) binding assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DHX8-IN-1 (Compound 53) is a potent, specific inhibitor of spliceosomal DEAH-box RNA helicase DHX8, inhibits DHX9 ATP-hydrolysis with IC50 of 43 nM in biochemical ADP-Glo assays, and 120 nM in RNA FA (fluorescence anisotropy) binding assays.

物理化学性质&存储条件

分子量 392.52
分子式 C23H24N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-((2-(4-(isopropylamino)phenyl)-1-phenylethyl)thio)nicotinic acid

参考文献

1. Read BJ, et al. J Med Chem. 2026 Aug 13;69(15):18277-18299.

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