DHPS inhibitor GC7 | DHPS inhibitor | Probechem Biochemicals

Chemical Structure : DHPS inhibitor GC7

CAS No.: 150417-90-6

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DHPS inhibitor GC7 (N1-guanyl-1,7-diaminoheptane)

货号: PC-27197Not For Human Use, Lab Use Only.

GC7 (N1-guanyl-1,7-diaminoheptane) is a high affinity, effective deoxyhypusine synthase (DHPS) inhibitor with Ki of 10 nM, inhibits spermidine-dependent hypusine-eIF5A activation.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

GC7 (N1-guanyl-1,7-diaminoheptane) is a high affinity, effective deoxyhypusine synthase (DHPS) inhibitor with Ki of 10 nM, inhibits spermidine-dependent hypusine-eIF5A activation.
GC7 inhibits NB cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
GC7/DFMO (ODC inhibitor) combination approach specifically inhibits both spermidine biosynthesis and post-translational, spermidine-dependent hypusine-eIF5A activation, induces apoptotic cell death in neuroblastoma.

物理化学性质&存储条件

分子量	270.35
分子式	C8H22N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(7-Aminoheptyl)guanidine sulfate

参考文献

1. Bandino A, et al. Cell Oncol (Dordr). 2014 Dec;37(6):387-98.

2. Tang DJ, et al. Hepatology. 2010 Apr;51(4):1255-63.

3. Schultz CR, et al. Biochem J. 2018 Jan 31;475(2):531-545.

4. J Jakus, et al. J Biol Chem. 1993 Jun 25;268(18):13151-9.

DHPS inhibitor GC7 (N1-guanyl-1,7-diaminoheptane)

生物&药学活性

物理化学性质&存储条件

参考文献

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DHPS inhibitor GC7 (N1-guanyl-1,7-diaminoheptane)

生物&药学活性

物理化学性质&存储条件

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